Psilocybin-Assisted Therapy A Modern Approach to Mental Health
Where thousands of years of ancient wisdom meets evidence-based mental health care — grounded in an IFS-based, ACT-informed clinical framework. Colorado is leading the nation, and we're proud to be part of it.
A Fundamentally Different Approach
For thousands of years, cultures around the world have worked with psilocybin mushrooms for healing, insight, and spiritual growth. Today, Colorado stands at the forefront of bringing this tradition into regulated therapeutic practice.
Many people reach a point where standard medications or talk therapy feel limited — leaving them stuck in persistent emotional patterns or unresolved symptoms. Psilocybin-assisted therapy offers a fundamentally different pathway, rooted in natural medicine and supported by a growing body of clinical research.
What makes our practice distinct is the clinical framework we hold around the medicine: Internal Family Systems (IFS) and Acceptance & Commitment Therapy (ACT) — two evidence-based modalities that prepare you for the medicine and help translate what surfaces into lasting change. The medicine softens defenses; the framework gives you a way to work with what's underneath.
With the passage of Proposition 122 in 2022 and the opening of licensed healing centers in 2025, The Psychedelic Therapy Den offers psilocybin-supported services under full regulatory compliance with the Colorado Department of Regulatory Agencies (DORA) — creating a safe, structured, and intentional setting for healing.
Neuroplasticity & New Neural Pathways
Psilocybin stimulates BDNF, promoting the formation of new neural connections — allowing the brain to escape entrenched patterns of depression, anxiety, and trauma that standard treatments often cannot reach.
Carhart-Harris et al., 2021 · Imperial College LondonDefault Mode Network Reset
Psilocybin temporarily quiets the brain's Default Mode Network — the region behind rumination and self-criticism — creating a window of genuine openness and psychological flexibility.
Carhart-Harris et al., 2014 · PNASProven, Lasting Clinical Outcomes
NIH-funded studies show significant, lasting relief from treatment-resistant depression, addiction, and psychological distress related to serious illness — often after just one to three sessions.
Davis et al., 2021 · JAMA PsychiatryPsilocybin: Naturally Occurring, Non-Habit-Forming
Psilocybin is a naturally occurring compound found in certain species of mushrooms. When used in a therapeutic setting, it temporarily alters patterns of consciousness in ways that support emotional insight, expanded awareness, and meaningful self-reflection.
A typical session lasts between two and six hours, depending on dosage, setting, and individual physiology. Modern scientific interest expanded dramatically after a 2006 Johns Hopkins study demonstrated both psilocybin's strong safety profile and the potential for lasting positive effects from a single guided experience.
Since then, research has continued worldwide — examining applications for depression, trauma-related symptoms, substance use disorders, and anxiety, particularly in individuals facing serious illness.
Crucially, the neurobiological changes psilocybin produces — softened defenses, quieted self-criticism, increased openness — are precisely the conditions where evidence-based therapies like IFS and ACT do their deepest work. The medicine creates the opening; the clinical framework gives that opening direction.
Strong Safety Profile
Clinical research consistently confirms psilocybin is non-addictive and carries an excellent safety record when administered in a structured, supervised context. Guiding someone through an expanded state of consciousness requires clinical skill, presence, and a deep commitment to safety — which is exactly what our licensed facilitators bring.
Johnson et al., 2008 · Journal of PsychopharmacologyEmotional Insight & Expanded Awareness
Experiences often include meaningful changes in mood, perception, and thought patterns — creating access to emotional material and new perspectives that are difficult or impossible to reach through ordinary states of consciousness.
Psychological Flexibility & Defusion
Emerging research shows psilocybin substantially increases psychological flexibility — the central mechanism of ACT — supporting acceptance of difficult experiences and a less-fused, more workable relationship with thoughts long after the session ends.
Davis et al., 2020 · Watts & Luoma, 2020Access to Inner Parts & Patterns
The same softening of defenses that allows for emotional insight also creates space for the protective parts of the psyche to relax. From a grounded state of Self-energy, clients can engage what's been beneath the surface — meeting old wounds with curiosity rather than avoidance.
Psychosomatic & Chronic Conditions
Clinical experience indicates potential benefits for stress-related physical symptoms including headaches and digestive concerns — conditions often connected to unresolved emotional patterns or chronic nervous system activation.
Beyond Symptom Relief
Many clients report increased clarity, emotional openness, spiritual insight, and long-term shifts in perspective — changes that extend well beyond symptom reduction into a fundamentally different relationship with themselves and their lives.
Griffiths et al., 2016 · Journal of PsychopharmacologyThe Medicine Creates the Opening. The Framework Gives It Direction.
Psilocybin alone is not therapy. What turns a powerful experience into lasting change is the clinical structure built around it — preparation that meets you where you are, presence during the journey, and integration that translates insight into a different way of living. Our framework rests on two evidence-based modalities working together: Internal Family Systems (IFS) and Acceptance & Commitment Therapy (ACT).
Internal Family Systems (IFS)
A parts-based therapy that recognizes the mind as a system of distinct inner voices — protectors that work hard to keep you safe, exiles that carry old pain, and a calm, compassionate core Self beneath them all. We help you build a curious, non-judgmental relationship with every part of who you are, so the parts carrying burdens can finally be witnessed and released.
Acceptance & Commitment Therapy (ACT)
A modern, mindfulness-based therapy focused on psychological flexibility — making room for difficult thoughts and feelings instead of fighting them, unhooking from the stories the mind tells, and orienting your actions toward what truly matters to you. Recent research identifies psychological flexibility as a core mechanism through which psilocybin produces lasting change.
Both modalities pair naturally with psilocybin — the medicine itself softens defenses, invites openness, and lets protective parts relax, so the work of acceptance, defusion, and unburdening can unfold from a place of clarity rather than effort.
Is This Path Right for You?
Your physical and emotional wellbeing guide every aspect of our care. Psilocybin has a strong safety profile when administered in a structured and supervised environment — but it is not appropriate for everyone.
We conduct a thorough intake and screening process with every client. In certain cases, written medical clearance from a physician is required. This reflects our commitment to ethical, responsible, and client-centered care. If psilocybin therapy isn't the right fit right now, we will help you find what is.
We encourage all prospective clients to consult their physician regarding medical conditions, medications, or concerns about suitability before reaching out.
- Persistent depression, including treatment-resistant
- Anxiety, OCD, and panic disorders
- PTSD and complex trauma (C-PTSD)
- Grief, loss, and prolonged bereavement
- Substance use and addiction recovery
- End-of-life distress and chronic illness
- Burnout, existential distress, loss of meaning
- Stress-related physical conditions
- Personal growth, self-discovery, spiritual exploration
- History of psychotic spectrum disorders
- Current use of antipsychotic medications
- Specific antidepressants (assessed case by case)
- Significant cardiovascular or kidney conditions
- Active psychiatric crisis
- Pregnancy or nursing
- Under 21 years of age (Colorado law)
These conditions don't automatically disqualify — they require documented physician approval before services begin.
Individual & Group Psilocybin Therapy
The Psychedelic Therapy Den offers full-spectrum psilocybin-assisted therapy — preparation, guided sessions, and integration — in both individual and group formats. Both pathways use the same IFS-based, ACT-informed clinical framework. Choose the structure that best supports your goals.
Individual Psilocybin Therapy
The highest level of personalized care and therapeutic attunement. Preparation, the psilocybin experience, and integration are paced entirely around your personal history, emotional needs, and nervous system capacity — anchored in our IFS-based, ACT-informed framework throughout every phase.
Especially supportive for those working with trauma, depression, anxiety, grief, or major life transitions. Continuous therapeutic presence throughout every phase — in a completely private studio.
Group Psilocybin Therapy
A different but equally powerful pathway. Professionally facilitated group sessions offer shared intention, relational insight, and the experience of being witnessed in a safe and supportive community — with the same IFS-based, ACT-informed preparation and integration as individual work.
Well-suited for those seeking connection, creative or spiritual exploration, or a more accessible entry into psychedelic work. Small cohorts allow for individualized support within a collective container.
Your Journey, Step by Step
Every therapeutic journey at The Psychedelic Therapy Den is intentionally structured and uniquely tailored — with IFS and ACT woven through every phase. Each experience unfolds through collaboration between you and your facilitator.
Free Consultation
A no-cost exploratory call with Michael Biggans. Space for your questions, discussion of goals, and an honest determination of whether psilocybin therapy is the right next step — with no pressure or obligation.
No cost · No commitmentPreparation
1–3 sessions exploring your history, parts mapping, values, intentions, and any fears or concerns. We build genuine trust and safety before anything else, and introduce the ACT skills — acceptance, willingness, defusion — that will support you through whatever arises. May be conducted in person or remotely.
Session Day
You arrive at our licensed Denver healing center. Dosage and comfort protocols already agreed upon. From a grounded state of Self-energy and self-as-context, you're held safely through whatever arises — your facilitator providing continuous therapeutic presence, containment, and emotional care throughout.
Integration
Post-session work to unburden the parts that surfaced, defuse from old stories the mind has been telling, and translate insight into committed, value-aligned action. Some clients choose ongoing integration or additional journeys depending on their goals.
Colorado's Natural Medicine Regulations
Colorado's natural medicine regulations differ from traditional medical models. Psilocybin-assisted therapy operates under its own distinct legal framework — designed specifically for this context.
We are a DORA-licensed healing center (NMHC-00048) operating in full compliance with Colorado's Natural Medicine Health Act (Proposition 122) and 4 CCR 755-1. Your experience here is fully legal, regulated, and professionally accountable.
Ready to Explore Whether This Is Right for You?
Begin with a free, no-commitment consultation with Michael Biggans. We are happy to explore whether psilocybin-assisted therapy may be a supportive next step in your healing journey — and to help you find the right path if it isn't.